I’m a Neuroscientist
Hi, my name is Martin. I’m a Neuroscientist at NeuCyte.
Check out my CV and contact me.
I am a highly motivated, results-driven Ph.D. level Scientist with Postdoctoral and industry experience. I have more than 15 years bench-side experience in cell biology and human iPSCs with expertise in advanced techniques in imaging, molecular biology, high-throughput screening, and cell line development.
Disease Modeling
Develop iPSC-based disease models in traditional 2D and advanced 3D systems. Specialize in rare diseases with unknown phenotypes.
Cell Manufacturing
Large scale manufacturing of iPSC-derived neuronal cell types including glutamatergic neurons, GABAergic neurons, and astrocytes.
Assay Development
Use iPSC-derived disease models to develop phenotypic and functional assays for drug screening applications.
Public Engagment
Present scientific findings at conferences and public engagement events in the form of posters and seminars.
Experience
Head of Commercial Neural Products
NeuCyte Inc.
Mountain View, USA
2022 – Present
Postdoctoral Scholar
Academia Sinica
Taipei ,Taiwan
2019 – 2022
Freelance Specialist Editor
Cactus Communications
2018 – 2019
Departmental Technician
University College London
London, UK
2009 – 2018
Education
Ph.D. Neuroscience
University College London
London, UK
2018
B.Sc. Biology & Spanish
Dalhousie University
Halifax, Canada
2008
Awards
Academia Sinica Postdoctoral Scholar
2021
Academia Sinica Postdoctoral Fellow
2019
Publications
- Lin C.J.,ChengY.C.,Chen H.C.,Chao Y.K.,Nicholson M.W.,Yen E.C.L.,Kamp T.J.,Hsieh P.C. 2022. Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice. Theranostics; Oct 17;12(17):7319-7334.ย
- Nicholson, M. W., Huang, C.Y., Wang, J.Y., Ting, C.Y., Cheng, Y.C., Chan, D., Lee, Y.C., Hsu, C.C., Hsu Y.H., Chang, C.M.C., Hsieh, M.L., Cheng, Y.Y., Hsu, Lin, Y.L., Chen, C.H., Hsu, Y.H., Wu, Y.T., Hacker, T.A., Wu, J.C., Kamp, T.J., Hsieh, P.C.H. 2022. Cardio and neurotoxicity of selected anti- COVID-19 drugs. Pharmaceuticals, 15(6), 765.
- Nicholson, M. W., Ting, C. Y., Chan, D. Z. H., Cheng, Y. C., Lee, Y. C., Hsu, C. C., Huang, C. Y., Hsieh, P. C. H. 2022. Utility of iPSC-derived cardiomyocytes and neurons for disease modeling, drug development, and cell therapy. Cells. 11, 1853.
- Huang, C.Y., Nicholson, M. W. (Co-first author), Wang, J.Y., Ting, C.Y., Tsai, M.H., Cheng, Y.C., Liu, Chan, D., Lee, Y.C., Hsu, C.C., Hsu Y.H., Yang, C.F., Chang, C.M.C., Ruan, S.C., Lin, P.J., Lin, J.H., Chen, L.L., Hsieh, M.L., Cheng, Y.Y., Hsu, W.T., Lin, Y.L., Chen, C.H., Hsu, Y.H., Wu, Y.T., Hacker, T.A., Wu, J.C., Kamp, T.J., Hsieh, P.C.H. 2022. Population-based high-throughput drug screen of human iPSC-derived cardiomyocytes and neurons. Cell Rep. 39, 1.
- Chen, CY., Lee, D.S., Choong, O.K., Chang S.K., Hsu, T., Nicholson, M. W., Liu, LW., Lin, PJ., Ruan, SC., Lin, SW., Hu, CY., Hsieh, P. C. et al. 2021. Cardiac-specific microRNA-125b deficiency induces perinatal death and cardiac hypertrophy. Sci Rep 11, 2377.
- Petrache, A. L., Khan, A. A., Nicholson, M. W., Monaco, A., Kuta-Siejkowska, M., Haider, S., Hilton, S., Jovanovic, J. N. & Ali, A. B. 2020. Selective modulation of alpha 5 GABAA receptors exacerbates aberrant inhibition at key hippocampal neuronal circuits in APP mouse model of Alzheimerโs disease. Front. Cell. Neurosci., 14, 346.
- Huang, C. Y., Li, L. H., Hsu, W. T., Cheng, Y. C., Nicholson, M. W., Liu, C. L., Ting, C. Y., Ko, H. W., Hsu, S. H, Wen, C. H., Yan, Z., Huang, H. P., Su, H. L., Chiang, P. M., Shen, C. N., Chen, H. F., Yen, B. L., Lu, H. N., Hwang, S. M., Chiou, S. H., Ho, H. N., Wu, J. Y., Kamp, T. J., Wu, J. C., Hsieh, P. C. 2020. Copy Number Variant Hotspots in Han Taiwanese Population Induced Pluripotent Stem Cell Lines – Lessons from Establishing the Taiwan Human Disease iPSC Consortium Bank. J. Biomed. Sci., 27, 92.
- Huang, C. Y., Liu, C. L., Ting, C. Y., Chiu, Y. T., Cheng, Y. C., Nicholson, M. W., Hsieh, P. C. 2019. Human iPSC banking: Barriers and opportunities. J Biomed Sci. 26, 87.
- Nicholson, M. W., Sweeney A., Peckle, E., Alam, S., Ali, A. B., Duchen, M., Jovanovic, J. N. 2018. Diazepam-induced loss of inhibitory synapses mediated by PLC/Ca2+/calcineurin signalling downstream of GABAA receptors. Mol Psychiatry, 23,1851.
- Brown, L. E., Nicholson, M. W., Arama, J. E., Mercer, A., Thomson, A. M. & Jovanovic, J. N. 2016. gamma-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains. J Biol Chem, 291, 13926.
- Brown,L.E.,Fuchs,C.,Nicholson,M.W.,Stephenson,F.A.,Thomson,A.M.&Jovanovic,J.N.2014. Inhibitory synapse formation in a co-culture model incorporating GABAergic medium spiny neurons and HEK293 cells stably expressing GABAA receptors. J Vis Exp, e52115.